Which SSRI is best for QT prolongation?
Sertraline may be the best first-line antidepressant for patients at risk for QT prolongation. Higher doses of citalopram may be appropriate in some patients with careful selection and judicious monitoring.
Which SSRI has the least QT prolongation?
Based on current literature, fluoxetine, fluvoxamine, and sertraline appear to have similar, low risk for QT prolongation, and paroxetine appears to have the lowest risk.
Do all SSRIs cause QT prolongation?
QT prolongation appears to be a class effect for all selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), and also occurs with venlafaxine. The potential for QT prolongation to occur should be considered as part of the risk benefit assessment prior to prescribing an antidepressant.
What antidepressants cause prolonged QT interval?
The following mean increases in QTc were fluoxetine, 13.0 ms (12.4–13.6), paroxetine, 12.4 ms (11.6–13.2), sertraline, 11.6 ms (10.3–12.9), and citalopram, 10.4 ms (9.2–11.6). Furthermore, there have been case reports of TdP with citalopram and fluoxetine in women over the age of 80 years.
Which SSRI has least drug interactions?
Citalopram and sertraline, which have relatively little effect on the P450 system and wash out of the body relatively quickly, are the least likely of the SSRIs to interact with a replacement drug.
Does Lexapro prolong QT interval?
Escitalopram is associated with an increased risk of QT prolongation at supratherapeutic doses. Citalopram and escitalopram should be used with caution in patients with multiple risk factors for QT prolongation.
Is Prozac stronger than Zoloft?
Which is More Effective? Both Prozac and Zoloft are considered powerful mental health medications, comparably effective at treating depression and reducing anxiety for the patients who take them. A few clinical trials suggest that Zoloft may have less serious side effects than Prozac.
Which SSRI has the most drug interactions?
Among the SSRIs, paroxetine is the most potent in vitro inhibitor of CYP-2D6, although it affects other CYP isoforms only minimally. Paroxetine therefore has the potential to cause clinically significant drug interactions when coadministered with CYP-2D6 substrates.
Which SSRI is safest?
Citalopram and escitalopram have been considered the safest among the SSRIs with respect to potential for liver injury [41].
Does Lexapro prolong QTc?
Does Zofran prolong QTc?
GlaxoSmithKline (GSK), the manufacturer of Zofran, was required by FDA to conduct a thorough QT study to assess the potential for the drug to prolong the QT interval. Preliminary review of the study results shows that QT prolongation occurs in a dose-dependent manner.
How do you calculate QT interval?
The QT interval shortens at faster heart rates
What is the measurement of a normal QT interval?
If an ECG is ordered to “rule out” LQTS,the computer-derived QTc must be manually verified.
What causes prolongation of the QT interval?
LQTS1: Emotional stress or exercise,especially swimming or diving
Does Zoloft increase QT interval?
The effect of steady-state supratherapeutic sertraline (Zoloft) on QT interval was assessed in a single-center, randomized, 3-way crossover, double-blind, placebo- and moxifloxacin-controlled thorough QT study. Healthy adults received sertraline 400 mg/day, moxifloxacin 400 mg, and placebo, with a washout period (≥14 days) between treatments.