What is the RERE gene?
The RERE gene provides instructions for making a protein that is critical for normal development before birth. This protein interacts with other proteins called transcription factors, which control the activity (transcription) of particular genes.
What is Rere syndrome?
Disease definition. A rare genetic multiple congenital anomalies/dysmorphic syndrome characterized by global developmental delay, intellectual disability, hypotonia, seizures, and autism spectrum disorder.
How are immediate early genes activated?
Immediate Early Genes Are Activated by Latent Transcription Factors After Learning. Immediate early gene (IEG) expression is directly induced by latent transcription factors, so protein synthesis is not required for expression of these genes after a stimulus.
What would happen without gene regulation?
Cells would have to be enormous if every protein were expressed in every cell all the time. The control of gene expression is extremely complex. Malfunctions in this process are detrimental to the cell and can lead to the development of many diseases, including cancer.
Where are immediate early genes found?
nerve cells
2 Immediate Early Genes. Immediate early genes (IEGs) are activated rapidly inside nerve cells by extracellular stimuli without the need of intermediate proteins synthesis.
What are delayed response genes?
By cDNA cloning, we have identified genes that are activated after a delay of a few hours and several hours prior to serum-induced DNA replication. Activation of these delayed early response genes requires new protein synthesis, presumably the synthesis of immediate-early transcription factors described previously.
What can regulate the functioning of a gene?
Gene regulation is accomplished by a variety of mechanisms including chemically modifying genes and using regulatory proteins to turn genes on or off.
Why do genes need to be regulated?
Gene regulation is an important part of normal development. Genes are turned on and off in different patterns during development to make a brain cell look and act different from a liver cell or a muscle cell, for example. Gene regulation also allows cells to react quickly to changes in their environments.
What is the role of immediate early genes?
Abstract. Immediate early genes (IEGs) are a class of genes that show rapid and transient but protein synthesis-independent increases in expression to extracellular signals such as growth factors and neurotransmitters.
Which of the following enzymes transcribe late genes?
Baculoviruses encode a novel RNA polymerase composed of four subunits that transcribes late and very late genes and that recognizes the unique promoter consensus sequence described above.
What is gene regulation and why is it important?