What is clopidogrel made from?
Each tablet contains hydrogenated castor oil, hydroxypropyl cellulose, mannitol, microcrystalline cellulose and polyethylene glycol 6000 as inactive ingredients. The pink film coating contains ferric oxide, hypromellose 2910, lactose monohydrate, titanium dioxide and triacetin.
What functional groups are present in clopidogrel?
A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer).
What kind of chemical is clopidogrel?
Clopidogrel is a thienopyridine compound, structurally related to ticlopidine, which inhibits ADP-induced platelet aggregation [1].
What is the mechanism of action of clopidogrel?
The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP- mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. This action is irreversible.
Where is clopidogrel manufactured?
S made at a factory in India, due to quality concerns about the heart drug. Plavix, or clopidogrel, is sold as a brand by Sanofi-Aventis SASY.PA and Bristol-Myers Squibb BMY. N. It is the world’s second biggest selling medicine, with worldwide sales of more than $9 billion a year.
What is generic for clopidogrel?
Clopidogrel, the generic Plavix, is used to treat patients who have had a recent heart attack, but that’s not all. Here are a few ways clopidogrel helps us out: – It is used to stop heart attacks. – It is used to stop strokes.
Where is clopidogrel absorbed?
Clopidogrel is a prodrug that is absorbed in the intestine [3,4] and activated in the liver [5]. The conversion of clopidogrel to its active metabolite requires two sequential oxidative steps.
What is the target of clopidogrel?
P2Y12, a new platelet ADP receptor, target of clopidogrel.
Where is generic Plavix made?
India
LONDON, March 25 (Reuters) – The European Medicines Agency has recommended the recall of all batches of generic Plavix from Swiss drugmaker Acino ACIN. S made at a factory in India, due to quality concerns about the heart drug.
What is the brand name of clopidogrel?
Clopidogrel oral tablet is available as both a generic and brand-name drug. Brand name: Plavix. Clopidogrel only comes in the form of a tablet you take by mouth. Clopidogrel is used to prevent heart attack and stroke.
Are pravastatin and Pravachol the same?
Pravastatin is a generic medication used to lower cholesterol and prevent complications caused by high cholesterol levels. The brand name of pravastatin is Pravachol.