What does high immunoglobulin M mean?
If your immunoglobulin level is high, it might be caused by: Allergies. Chronic infections. An autoimmune disorder that makes your immune system overreact, such as rheumatoid arthritis, lupus, or celiac disease.
What is the function of immunoglobulin M?
Immunoglobulin (Ig) M is the first antibody isotype to appear during evolution, ontogeny and immune responses. IgM not only serves as the first line of host defense against infections but also plays an important role in immune regulation and immunological tolerance.
What does low immunoglobulin M mean?
Low Immunoglobulin M Low levels of IgM may mean your immune system is not working optimally. Because this antibody helps provide protection against bacteria and viruses, having low IgM levels has been associated with a higher risk of recurring infections [8].
What do immunoglobulins do?
Immunoglobulins, also known as antibodies, are glycoprotein molecules produced by plasma cells (white blood cells). They act as a critical part of the immune response by specifically recognizing and binding to particular antigens, such as bacteria or viruses, and aiding in their destruction.
Is High IgM serious?
Hyper IgM syndromes are caused by very rare, one-in-a-million, and potentially life-threatening genetic mutations that severely compromise the immune system and resulting in the individual’s inability to produce antibodies. Patients with hyper IgM are at significant risk for opportunistic and repeated infections.
How do you treat high IgM?
Chemotherapy is a drug that destroys cells in the body that grow quickly. You can get this treatment as a pill or intravenously, which means through your veins. Chemotherapy for Waldenstrom’s disease is designed to attack the abnormal cells producing the excess IgM.
Is IgM deficiency serious?
Selective IgM deficiency is more common than previously recognized and is likely a heterogeneous disorder. Patients with SIGMD may be asymptomatic; however, commonly present with chronic and recurrent infections; some of them could be serious and life threatening.
What is normal range for IgM?
Normal Ranges Adult: IgG 6.0 – 16.0g/L. IgA 0.8 – 3.0g/L. IgM 0.4 – 2.5g/L.
What is the treatment for low IgM?
Treatment may include prompt treatment of infections, taking measures to prevent infections, prophylactic antibiotics , and immune globulin therapy.
What is immunoglobulin M in blood test?
The Immunoglobulin M Test is used to measure the amount of IgM antibodies in the blood. The IgM test is also used to assess a person’s immune system and also to detect and monitor an excess or deficiency of different Immunoglobulin class.
What is IgG positive?
IgG antibodies remain in the blood after an infection has passed. These antibodies indicate that you may have had COVID-19 in the recent past and have developed antibodies that may protect you from future infection.
What autoimmune diseases cause high IgM?
Autoreactive IgM levels are greatly elevated in various autoimmune diseases, such as SLE, rheumatoid arthritis, and autoimmune liver diseases. This association likely does not reflect a causative relationship between autoreactive IgM and disease occurrence.