Is LRP1 a tumor suppressor?

Is LRP1 a tumor suppressor?

Cancer. LRP1 is involved in tumorigenesis, and is proposed to be a tumor suppressor. Notably, LRP1 functions in clearing proteases such as plasmin, urokinase-type plasminogen activator, and metalloproteinases, which contributes to prevention of cancer invasion, while its absence is linked to increased cancer invasion.

Is lrp-1 expression associated with colon cancer molecular or morphological profile?

The clinical and prognostic impact of LRP-1 expression in colon cancer and its association with a particular molecular or morphological profile has not been studied to date. In this work, the investigators will study the immunohistochemical and genic expression of LRP-1 in a series of colorectal cancers.

How does LRP1b induce high mutation rate in tumors?

The mechanisms through which LRP1B induce high mutations rate in tumors are still unknown and require future investigation. An investigation of a possible role of LRP1B in response to immune check-point blockade treatment in other cancer types (HNSC, ESCC, STAD, etc.) is warranted to study.

What is the role of LRP1 in apoptosis?

LRP1 is alsocontinuously endocytosed from the membrane and recycled back to the cell surface. Though the role of LRP1 in apoptosis is unclear, it is required for tPA to bind LRP1 in order to trigger the ERK1/2 signal cascade and promote cell survival.