Is depression a heterogeneous disorder?
Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a unitary disease entity, encompassing a broad spectrum of psychopathology arising from distinct pathophysiological mechanisms.
What happens with MAOI and tyramine?
If you take an MAOI and you eat high-tyramine foods, tyramine can quickly reach dangerous levels. This can cause a serious spike in blood pressure and require emergency treatment. Avoid consuming foods that are high in tyramine if you take an MAOI.
What is a depression simple definition?
Overview. Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. Also called major depressive disorder or clinical depression, it affects how you feel, think and behave and can lead to a variety of emotional and physical problems.
Is depression Genetic Google Scholar?
Recent findings from genome-wide association studies are reviewed and future directions discussed. Despite all efforts, thus far, no single genetic variation has been identified to increase the risk of depression substantially.
How do MAOIs treat depression?
Antidepressants such as MAOIs ease depression by affecting chemical messengers (neurotransmitters) used to communicate between brain cells. Like most antidepressants, MAOIs work by ultimately effecting changes in the brain chemistry that are operational in depression.
Why does tyramine cause hypertensive crisis?
In humans, if monoamine oxidase inhibitors (MAOI’s) and foods high in tyramine are ingested, tyramine is not degraded and a hypertensive crisis can result from tyramine displacing stored monoamines such as dopamine, norepinephrine, and epinephrine from synaptic vesicles.
What are examples of depression?
What Is Depression?
- Feeling sad or having a depressed mood.
- Loss of interest or pleasure in activities once enjoyed.
- Changes in appetite — weight loss or gain unrelated to dieting.
- Trouble sleeping or sleeping too much.
- Loss of energy or increased fatigue.
What is the operational definition of depression?
For example, depression can be operationally defined as people’s scores on a paper-and-pencil depression scale such as the Beck Depression Inventory, the number of depressive symptoms they are experiencing, or whether they have been diagnosed with major depressive disorder.
How does depression affect genes?
Depression does not have a clear pattern of inheritance in families. People who have a first-degree relative (for example, a parent or sibling) with depression appear to have a two to three times greater risk of developing the condition than the general public.