How much DIM Should a breast cancer patient take?

How much DIM Should a breast cancer patient take?

How much DIM should be taken? Studies show the most effective amount of supplemental DIM is 30 mg. of absorbable DIM per dose, with daily doses of 60 mg. for women and 120 mg.

Is DIM safe for breast cancer?

DIM has been intensely studied as a possible therapeutic agent in cancer treatment, especially for breast cancer. Studies report that DIM treatment promotes cellular growth arrest of cancer cells, as well as a decrease in mammary tumor formation in DMBA-treated rats [16, 24, 30].

Does estrogen make breast cancer worse?

Studies have also shown that a woman’s risk of breast cancer is related to the estrogen and progesterone made by her ovaries (known as endogenous estrogen and progesterone). Being exposed for a long time and/or to high levels of these hormones has been linked to an increased risk of breast cancer.

Can I take DIM instead of tamoxifen?

In patients taking tamoxifen for breast cancer, daily DIM promoted favorable changes in estrogen metabolism and circulating levels of SHBG. Further research is warranted to determine whether decreases in tamoxifen metabolites, including endoxifen, with DIM would attenuate the clinical benefit of tamoxifen.

What are the side effects of Diindolylmethane?

The most common side effects include headache, nausea, vomiting, gas, and diarrhea. Taking larger doses of diindolylmethane is possibly unsafe. Taking 600 mg of diindolylmethane daily might lower sodium levels in some people.

Does DIM block aromatase?

Additionally, DIM has been shown to inhibit an enzyme called aromatase, which converts testosterone to estrogen ( 1 ). While cruciferous vegetables are the primary food source of DIM, you would need to eat several servings every day to reap this compound’s benefits ( 1 ).

Is DIM good for low estrogen?

DIM supplements appear to help adjust the hormone estrogen. A few clinical trials have shown that it supports healthy estrogen levels, lowering the risk of certain cancers and diseases like lupus that are linked to estrogen.

What causes estrogen positive breast cancer?

Some breast cancers develop due to a problem involving hormones, including estrogen and progesterone. These hormones play a role in telling breast cells to grow. In hormone receptor-positive breast cancer, the receptors for hormones cause breast cells to grow in an uncontrolled way.

Should you take DIM if you have low estrogen?

Does Diindolylmethane block estrogen?

Diindolylmethane might act like estrogen in the body, but might also block estrogen effects. It appears to help destroy cancer cells and reduce swelling. People commonly use diindolylmethane for breast cancer, prostate cancer, and many other conditions, but there is no good scientific evidence to support these uses.

Is DIM good for postmenopausal?

After menopause, women’s bodies make less estrogen. So DIM may not have much benefit. The worst-case scenario is that DIM may further osteoporosis – thinning bones – by lowering your body’s ability to keep a healthy bone density.

Does dim cause breast cancer?

One pilot study suggests DIM may lead to changes in estrogen metabolism in postmenopausal women with a history of early stage breast cancer (4).

Does dim increase metabolite ratio in breast cancer patients taking tamoxifen?

In a RCT of estrogen receptor-positive breast cancer patients taking tamoxifen, daily DIM promoted an increase in the metabolite ratio of 2-hydroxyestrone (2-OHE1) (anti-tumorigenic) to 16α-hydroxyestrone (16α-OHE1) (pro-tumorigenic) . However, this increase was coupled with a reduction in metabolites from tamoxifen.

Does dim increase 2-hydroxyestrone levels?

In an RCT of estrogen receptor-positive breast cancer patients taking tamoxifen, daily DIM promoted an increase in the metabolite ratio of 2-hydroxyestrone (2-OHE1, anti-tumorigenic) to 16α-hydroxyestrone (16α-OHE1, pro-tumorigenic) (25). However, this increase was coupled with a reduction in metabolites from tamoxifen.

What are the effects of dim?

One of DIM’s primary effects involves the hormone estrogen. As we know, estrogen is important for both men and women, but too much of it can predispose to various cancers. For women, too much estrogen increases the risk for breast, ovarian, and endometrial cancers.