How common is hemoglobin D trait?
Hemoglobin D is inherited from your parents, like hair or eye color. If one parent has hemoglobin D trait, there is a 50% (1 in 2) chance with each pregnancy of having a child with hemoglobin D trait. Hemoglobin D trait is not a disease, and usually has no symptoms. You may have hemoglobin D trait and not know it.
What is β thalassemia trait?
Beta thalassemia is an inherited blood disorder in which the body doesn’t make as much beta globin as it should. Beta globin and alpha globin are building blocks of hemoglobin. Hemoglobin is the part of red blood cell (RBC) that carries oxygen throughout the body.
Does thalassemia trait cause low hemoglobin?
Thalassemia (thal-uh-SEE-me-uh) is an inherited blood disorder that causes your body to have less hemoglobin than normal. Hemoglobin enables red blood cells to carry oxygen. Thalassemia can cause anemia, leaving you fatigued. If you have mild thalassemia, you might not need treatment.
What is hemoglobin D disease?
People who have hemoglobin D disease have red blood cells that contain mostly hemoglobin D. Too much hemoglobin D can reduce the number and size of red blood cells in your body, causing mild anemia. Hemoglobin D disease is rare and usually does not cause serious health problems.
Where does hemoglobin D come from?
Hemoglobin D-Punjab was first discovered in the early 1950s in a mixed British and American family of Indian origin from the Los Angeles area; hence it is also sometimes called “D Los Angeles”. Hemoglobin D is the 4th most common hemoglobin variant.
What is Hb D-Punjab in pregnancy?
Haemoglobin D trait (heterozygous form) is an abnormal haemoglobin variant which when present is clinically asymptomatic but its coinheritance with other haemoglobinopathies like haemoglobin S (Hb S) or thalassemia can cause sickle cell disease and chronic haemolytic anaemia of moderate severity.
Can thalassemia trait turn into major?
Because the thalassemia trait is a genetic trait and not a health condition, it cannot “become worse” or change into one of the more serious forms of thalassemia that may require medical treatment.
How is beta thalassemia trait treated?
Treatment may include: Regular blood transfusions. Medicines to reduce extra iron from your body (called iron chelation therapy) Surgery to remove the spleen, if needed.
Can you donate blood if you have thalassemia trait?
Usually, individuals with hemoglobin levels that are too low are temporarily not permitted to donate blood. A low hematocrit level is one of the most common reason people are temporarily disqualified or “deferred” from donating blood, but some donors can actually have anemia and still be eligible to donate.
What is hemoglobin D carrier?
Haemoglobin is the substance in red blood cells that carries oxygen around your body. Being a carrier means you have inherited one usual haemoglobin gene called haemoglobin A from one biological parent and one haemoglobin D gene from your other biological parent. There are different types of haemoglobin D.
What are the two variants of hemoglobin D?
There are a number of hemoglobins termed Hemoglobin D (D-Los Angeles or D-Punjab, and D-Ibadan being the most common). These are all inherited variants of normal adult hemoglobin (hemoglobin A) and all have similar clinical implications.