What does BALB C stand for?
The name BALB is a concatenation of Bagg and Albino. From 1920, the progeny of the original colony were systematically inbred, sibling to sibling, for 26 generations over 15 years.
Why are BALB c mice used?
BALB/cJ mice are frequently used for a variety of immunological studies, in part because they demonstrate TH2-biased immune responses. BALB/c mice are particularly well known for the production of plasmacytoma on injection with mineral oil, forming the basis for the production of monoclonal antibodies.
Are BALB c mice wild type?
BALB/c wild-type mice were obtained from the Walter and Eliza Hall Institute for Medical Research and were maintained at the Peter MacCallum Cancer Centre.
How long do BALB c mice live for?
Survival analysis shows quite higher longevity (median age: about 29 months) in this population when compared with other BALB/c strains.
Are BALB c mice immunocompromised?
This mouse is inbred, and genetic monitoring results confirm it to be a BALB/c nude. The animal lacks a thymus, is unable to produce T-cells, and is therefore immunodeficient.
Do BALB c mice have an immune system?
Other studies revealed that in contrast to C57BL/6 mice, which show a Th1- and M1-dominant immune response, BALB/c mice show a more Th2- and M2-dominant immune response [17, 19].
Are BALB c mice inbred?
BALB/c Mouse BALB/c mice are inbred strain and now over 230 generations from their origin in New York in 1920. BALB/c mice are distributed globally and among the five most widely used inbred strains in biomedical research, particularly in immunology and infectious disease research.
How long do experimental mice live?
Inbred laboratory strains of mice are the most common mammalian models used in aging research. In well-maintained specific-pathogen-free animals, C57BL/6 mice should live 26-30 months on average. Mice in nature live 3-4 months on average and up to 18 months at the most.
How long do inbred mice live?
Survival curves varied dramatically among strains with median lifespans ranging from 251 to 964 days. Plasma IGF1 levels, which also varied considerably at each time point, showed an inverse correlation with median lifespan at 6 months (R=−0.33, P=0.01).
Are BALB c mice genetically modified?
Abstract. Genetically engineered mice are usually produced on a mixed genetic background and can be derived from several mouse strains including 129SvJ, C57BL6, and BALB/c.
Do BALB c mice have T cells?
CD3 pan T cells from BALB/c mice consist of both CD4 and CD8 T cells and make up approximately 33% of cells in the spleen of a typical adult animal.
Why are C57BL 6 mice used?
C57BL/6 mice is an inbred mouse strain originally developed for the study of antitumor activity and immunology, and is increasingly being used as an basic background strain. It is known that cell-mediated immunity and NK cell activity are of relatively high importance in determining immunological characteristics.
What are the characteristics of BALB/c mice?
Characteristics. BALB/c mice are useful for research into both cancer and immunology. According to Michael Festing’s Inbred Strains of Mice, BALB/c substrains are “particularly well known for the production of plasmacytomas on injection with mineral oil ,” an important process for the production of monoclonal antibodies.
What kind of animal is a BALB/c?
BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation.
What are BALB/c substrains known for?
According to Michael Festing’s Inbred Strains of Mice, BALB/c substrains are “particularly well known for the production of plasmacytomas on injection with mineral oil ,” an important process for the production of monoclonal antibodies. They are also reported as having a “low mammary tumour incidence,…
What is the meaning of BALB/c?
BALB/c. BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived.