Can minocycline cause pseudotumor cerebri?
Conclusion: Minocycline is a cause or precipitating factor in pseudotumor cerebri syndrome. Although most patients have prominent symptoms and are diagnosed promptly, others are asymptomatic and may have optic disk edema for a long period of time before diagnosis.
Can minocycline cause intracranial pressure?
Minocycline has been implicated in the development of elevated intracranial pressure (ICP), resulting in a syndrome that meets the most recent diagnostic criteria1 for idiopathic intracranial hypertension (IIH).
How common is intracranial hypertension from minocycline?
The WHO adverse reactions database documents 188 cases of intracranial hypertension with minocycline, 31 with tetracycline and 27 with doxycycline. One review of 162 cases of medicine-related BIH found that 9% were linked to minocycline, 5.5% to tetracycline and 1.2% to isotretinoin.
What medications should be avoided with pseudotumor cerebri?
Medications that are known to precipitate Pseudotumor CEREBRI (PTC) and should be AVOIDED:
- Tetracycline, Doxycycline, Minocycline (usually prescribed for treatment of Acne and Rosacea)
- Vitamin A and related compounds:
- Growth Hormone (rHGH, synthetic)
What are the side effects of taking minocycline?
Common side effects of Minocin include:
- nausea,
- vomiting,
- upset stomach,
- diarrhea,
- lightheadedness,
- dizziness,
- spinning sensation,
- unsteadiness,
Does minocycline cause anxiety?
For example, minocycline can block lipopolysaccharide-stimulated inflammatory cytokine secretion, sickness behavior and anhedonia [69]. On the other hand, minocycline is also an antibiotic, and antibiotic treatments have been shown to increase the risk for depression and anxiety [70, 71].
What drugs increase intracranial pressure?
Drugs most commonly associated with intracranial hypertension include vitamin A (at doses >25,000 IU daily) and related compounds (such as isotretinoin and all-trans retinoic acid), tetracycline-class antibiotics, recombinant growth hormone, and lithium.
How long does it take for doxycycline to cause intracranial hypertension?
The symptoms of raised intracranial pressure began one and three months after starting doxycycline. The cerebrospinal fluid pressure was substantially increased and with appropriate treatment and withdrawal of the drug fell to normal.
What does intracranial pressure feel like?
Classic signs of intracranial pressure include a headache and/or the feeling of increased pressure when lying down and relieved pressure when standing. 3 Nausea, vomiting, vision changes, changes in behavior, and seizures can also occur.
Does pseudotumor cerebri ever go away?
Pseudotumor cerebri, also called idiopathic intracranial hypertension (IIH), is a condition in which the pressure inside your skull is too high. This pressure can cause symptoms similar to those of a brain tumor. Most people completely recover with treatment.
What does a pseudotumor cerebri headache feel like?
Pseudotumor cerebri headaches usually feel like a headache that occurs at the back of the head or behind the eyes. The pain starts as a dull, aching pain that worsens at night or in the morning. They may be associated with vomiting as well.
What happens when you stop taking minocycline?
If IH develops, it usually goes away after minocycline is stopped; however, there is a chance of permanent vision loss or blindness. Get medical help right away if you have: severe/lasting headache, vision changes (such as blurred/double vision, decreased vision, sudden blindness), nausea/vomiting that doesn’t stop.
Can minocycline cause pseudotumor cerebri syndrome?
Withdrawal of minocycline and treatment for inc … Minocycline is a cause or precipitating factor in pseudotumor cerebri syndrome. Although most patients have prominent symptoms and are diagnosed promptly, others are asymptomatic and may have optic disk edema for a long period of time before diagnosis.
What are the outcome measures for minocycline-induced visual impairment?
The main outcome measures included resolution of headaches, transient visual obscurations, diplopia, papilledema, and visual fields static thresholds after withdrawal of minocycline and treatment for increased intracranial pressure.
Can minocycline cause severe hypersensitivity drug reactions?
Minocycline as possible cause of severe and protracted hypersensitivity drug reaction. Arch Dermatol. 1995;131:490–491. doi: 10.1001/archderm.131.4.490.
How long does it take for minocycline to stop working?
Minocycline was discontinued on the fourth day after the onset of the symptoms. Two days after minocycline withdrawal, treatment with steroids was introduced (methylprednisolone 60 mg daily) because of the severity of the symptoms. The patient improved quickly after steroid administration.