How do you administer Avastin?
Administration
- Administer as an intravenous infusion.
- First infusion: Administer infusion over 90 minutes.
- Subsequent infusions: Administer second infusion over 60 minutes if first infusion is tolerated. Administer all subsequent infusions over 30 minutes if second infusion over 60 minutes is tolerated.
How is Avastin supplied?
Injection: 100 mg/4 mL (25 mg/mL) or 400 mg/16 mL (25 mg/mL) clear to slightly opalescent, colorless to pale brown solution in a single-dose vial. None. Serious, and sometimes fatal, gastrointestinal perforation occurred at a higher incidence in patients receiving Avastin compared to patients receiving chemotherapy.
How do you dilute bevacizumab?
Withdraw necessary amount of Avastin and dilute in a total volume of 100 mL of 0.9% Sodium Chloride Injection, USP. Discard any unused portion left in a vial, as the product contains no preservatives. DO NOT ADMINISTER OR MIX WITH DEXTROSE SOLUTION. Do not administer as an intravenous push or bolus.
How is Avastin administered for GBM?
Avastin® (bevacizumab) is given as an infusion. That means you get Avastin through a small needle in your vein or through a port, which is a device placed under your skin. Because Avastin is given as an infusion, infusion-related reactions may occur.
How long does Avastin infusion last in your body?
Does this affect how long the drug’s side effects last? Not necessarily. Avastin can stay in your system for about 4 months after you stop using it. But its levels decrease steadily over that time.
Does Avastin prolong life?
“Avastin has helped people with five different incurable cancers; many have lived a longer time without their disease worsening, and in certain cases, Avastin has extended their lives,” says Charlotte Arnold, senior manager of corporate relations for Genentech.
How many patients are treated with Avastin?
Across indications, Avastin has been used to treat more than 2.2 million patients worldwide.
Is bevacizumab a chemo drug?
Avastin ® (bevacizumab) works differently than chemotherapy. Avastin is used with chemotherapy and hits your cancer from another angle. Avastin is a tumor-starving (anti-angiogenic) therapy. The purpose of Avastin is to prevent the growth of new blood vessels.
How long does Avastin work for glioblastoma?
The median PFS time was 3.5 months and the median OS time was 7.5 months. The PFS rate at 6 months was 21.5% and the OS rate at 12 months was 11.5%.
How often is Avastin given for glioblastoma?
Avastin dosing in recurrent glioblastoma
| Tumor type | Avastin dose | Avastin schedule |
|---|---|---|
| rGBM* | 10 mg/kg IV | Every 2 weeks |
How does Avastin make you feel?
Some people may experience mild or serious side effects during their Avastin treatment. Examples of Avastin’s more commonly reported side effects include: bleeding, such as nosebleeds or serious bleeding* headache.
How is Avastin administered?
Avastin is given as an infusion into a vein. A healthcare provider will give you this injection. Tell your caregivers if you feel dizzy, nauseated, light-headed, sweaty, or have a headache, shortness of breath, or chest pain during the injection. Avastin is usually given once every 2 or 3 weeks. You will need frequent medical tests.
What is Avastin used to treat in lung cancer?
Avastin, in combination with carboplatin and paclitaxel, is indicated for the first-line treatment of patients with unresectable, locally advanced, recurrent or metastatic non–squamous non–small cell lung cancer (NSCLC). Avastin is indicated for the treatment of recurrent glioblastoma (GBM) in adults.
How many carboplatin and paclitaxel are given with Avastin?
Patients were randomized (1:1:1) to carboplatin and paclitaxel without Avastin (CPP), carboplatin and paclitaxel with Avastin for up to six cycles (CPB15), or carboplatin and paclitaxel with Avastin for six cycles followed by Avastin as a single agent for up to 16 additional doses (CPB15+). Avastin was given at 15 mg/kg every three weeks.
How safe is Avastin?
The safety of Avastin was evaluated in 247 patients who received at least one dose of Avastin in a double-blind study (AVF4095g) in patients with platinum sensitive recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer [see Clinical Studies (14.9]