What is the chemical structure of fluconazole?
Fluconazole-d4
| PubChem CID | 25216506 |
|---|---|
| Molecular Formula | C13H12F2N6O |
| Synonyms | Fluconazole-d4 1124197-58-5 1,1,3,3-tetradeuterio-2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol DTXSID90649144 Fluconazole D4 (bismethylene D4) More… |
| Molecular Weight | 310.30 |
| Dates | Modify 2022-04-02 Create 2009-04-13 |
What is the mechanism of action of fluconazole?
Mechanism: Fluconazole works by altering the fungal cell membrane. It exerts its fungistatic effect by selectively inhibiting 14-alpha demethylase. This is a cytochrome P-450 enzyme that is necessary for synthesizing ergosterol, which is an important component of the fungal cell membrane.
What is the molecular formula of fluconazole?
C13H12F2N6OFluconazole / Formula
What is the chemical name for fluconazole?
Fluconazole | C13H12F2N6O – PubChem.
Where is fluconazole metabolized?
Fluconazole is metabolized minimally in the liver. Fluconazole is an inhibitor of CYP2C9, CYP3A4 and CYP2C19.
What are the contraindications of fluconazole?
Who should not take FLUCONAZOLE?
- low amount of magnesium in the blood.
- low amount of potassium in the blood.
- torsades de pointes, a type of abnormal heart rhythm.
- prolonged QT interval on EKG.
- abnormal EKG with QT changes from birth.
- abnormal liver function tests.
- pregnancy.
- chronic kidney disease stage 3A (moderate)
What is the function of fluconazole?
Fluconazole Capsules are one of a group of medicines called “antifungals”. The active substance is fluconazole. Fluconazole Capsules are used to treat infections caused by fungi and may also be used to stop you from getting a candidal infection. The most common cause of fungal infections is a yeast called Candida.
Can fluconazole and doxycycline be taken together?
Combination with doxycycline converts fluconazole from fungistatic to fungicidal, prevents the onset of drug resistance, and is also effective against a clinical isolate characterized by elevated resistance to fluconazole.
Is fluconazole fungistatic or fungicidal?
Fluconazole (FLC) is a well-known fungistatic agent that inhibits ergosterol biosynthesis. We showed that FLC exhibits dose- dependent fungicidal activity, and investigated the fungicidal mechanism of FLC on Candida albicans.
What is the pH of fluconazole?
Fluconazole is a white crystalline solid which is slightly soluble in water and saline. Fluconazole Injection, USP is an iso-osmotic, sterile, nonpyrogenic solution of fluconazole in a sodium chloride diluent. Each mL contains 2 mg of fluconazole and 9 mg of sodium chloride. The pH ranges from 4.0 to 6.5.
Can fluconazole and itraconazole be taken together?
Itraconazole solution is recommended for the treatment of oral and oesophageal candidosis in AIDS patients who are non-responsive to fluconazole, but a higher dose (up to 400 mg daily) and a longer treatment period (2 weeks, repeated if necessary) than for first-line therapy are recommended.
Does fluconazole interact with birth control?
Antifungal medications Antifungal ointments, creams, and powders that you apply to the skin do not interfere with oral contraception. “Antifungals such as fluconazole and itraconazole inhibit the enzyme that is partially responsible for the metabolism of birth control pills,” Dr. Torres says.
How does fluconazole work as an antifungal?
Fluconazole is a synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity.
What is the protein binding percentage of fluconazole?
The protein binding of fluconazole is low and estimated to be 11 to 12%. Fluconazole’s production and use as an antifungal agent may result in its release to the environment through various waste streams.
What is the photolysis potential of fluconazole?
Fluconazole does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight (SRC). (1) Lyman WJ et al; Handbook of Chemical Property Estimation Methods.
Is fluconazole a cytochrome P450 inhibitor?
Fluconazole. Fluconazole is an Azole Antifungal. The mechanism of action of fluconazole is as a Cytochrome P450 2C19 Inhibitor, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inhibitor. The chemical classification of fluconazole is Azoles. Fluconazole is a synthetic triazole with antifungal activity.