What are the two properties of a dendrimer in solution that can be used to increase the water solubility of a hydrophobic drug?
2). The unique properties of dendrimers including its superior host-guest chemistry, multivalent geometry, high aqueous solubility, high encapsulation efficiency and the adaptable surface architecture makes it an excellent drug solubilizing agent.
Are dendrimers hydrophobic?
The internal architecture of a dendrimer is usually hydrophobic due to hydrophobic interactions and hydrogen bond formations and is suitable for encapsulating hydrophobic drugs/bio-actives (Medina and El-Sayed, 2009).
How can you increase the solubility of a drug molecule?
There are various techniques to enhance the drug solubility such as particle size reduction, nanosuspension, use of surfactants, salt formation, solid dispersion, etc. From this article it may be concluded that solid dispersion is an important approach for improvement of bioavailability of poor water-soluble drugs.
What is PAMAM dendrimer?
PAMAM dendrimers are a family of highly branched and mono-disperse synthetic macromolecules with well-defined structures and compositions. Synthesis of these nanocarriers can be carried out through the divergent route.
Why are dendrimers used in drug delivery?
We have demonstrated the utility of PAMAM dendrimers for enhancing solubility, stability and oral bioavailability of various drugs. Drug entrapment and drug release from dendrimers can be controlled by modifying dendrimer surfaces and generations.
What is Pamam dendrimer?
What affects drug solubility?
Drug solubility depends on the pH of fluid, temperature, volume, and contents of fluid. The lipophilicity of a drug is also correlated with water solubility. The rate and extent of absorption can be altered by food.
How is solubility used in everyday life?
Famous Examples of Solubility in Daily Life Salt or sodium chloride – usually soluble in water at 20 ° C. Sugar usually dissolves in water molecules at 20 ° C. Gelatin – soluble in water in the presence of heat. Powdered juices are a mixture of sugar, flavorings, and preservatives, usually soluble in water at 20 ° C.
Why are dendrimers important?
Dendrimers used for enhancing solubility Dendrimer-based carriers offer the opportunity to enhance the oral bioavailability of problematic drugs. Thus, dendrimer nano carriers offer the potential to enhance the bioavailability of drugs that are poorly soluble and/or substrates for efflux transporters [70,71].
Which is the example of dendrimer?
Examples of several types of dendrimers include those which have immense applications in drug delivery including poly(amidoamine) (PAMAM) dendrimers, poly(propylene imine) (PPI) dendrimers, polyether-copolyester (PEPE) dendrimers, PEGylated dendrimers, peptide dendrimers, etc.